New Research: A Significant Link Between Cancers And Obesity

New Research: A Significant Link Between Cancers And Obesity

A dozen would be related to overweight, mainly those of the digestive organs or hormone-dependent organs.

A Significant Link Between Cancers And Obesity

Cancer is the second leading cause of death in the world. Among the identified risk factors, obesity. The global epidemic is part of the growing development of tumors. But, overweight could actually have less weight than estimated so far. A meta-analysis, published in the British Medical Journal, suggests that the majority of studies are of questionable quality.

Before reaching this conclusion, the team at Imperial College in London (UK) went through a fine-tooth comb 200 meta-analysis on the relationship between obesity and cancer, through several markers of overweight.

On the 36 analyzed cancers in the literature, a significant link emerges in only 11 localizations. The majority of these are cancers of the digestive organs or hormone-dependent tumors. These two types of cancers are known to be strongly influenced by adiposity.

Targeting Approaches

In detail, a strong association exists between body mass index (BMI) and cancers of the esophagus, the marrow, or the kidneys. For example, for each additional 5 points of BMI, the risk of colorectal cancer increases by 9% and that of bile duct cancer by 56%.

Depending on sex, other sites may emerge. Thus, overweight increases the likelihood of colon-rectum cancer in men and the endometrial cancer in women. In the latter case, the risk increases by 21% for each increase of 0.1 in the waist-to-hip ratio.

All these results should argue for a personalized approach to excess weight, according to the authors. “It is now clear that preventing excess weight can reduce the risk of developing certain cancers,” says Dr. Kostas Tsilidis. He calls on health systems to invest more in prevention … but also the research teams to be more rigorous. For the conclusion of the meta-analysis emphasizes that too little work leads to a solid level of proof. As a result, “substantial uncertainty persists for other forms of cancer.”


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